Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery

PLoS One. 2018 Jul 18;13(7):e0200440. doi: 10.1371/journal.pone.0200440. eCollection 2018.

Abstract

In this study, super paramagnetic iron oxide nanoparticles (SPIONs) were produced by chemical co-precipitation method, then it was constructed to be a core shell nanoparticle by functionalizing with SDS, loading with curcumin and coating with a biopolymer i.e. chitosan. Each step was analyzed microscopically and spectroscopically. The produced coreshell particles were between 40 and 45nm and these coreshell particles were utilized for drug delivery studies against cervical cancer cell line-HeLa cells. The coreshell SPIONs were found to be releasing curcumin in between 6 and 12 h, which was evidenced by increased apoptotic cells and increased caspase 3 expression in HeLa cells.

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Apoptosis / drug effects
  • Apoptosis / physiology
  • Caspase 3 / metabolism
  • Chitosan / chemistry
  • Curcumin / administration & dosage*
  • Curcumin / chemistry
  • Drug Carriers / chemical synthesis*
  • Drug Carriers / chemistry
  • Ferric Compounds* / chemistry
  • HeLa Cells
  • Humans
  • Magnetite Nanoparticles* / chemistry
  • Magnetite Nanoparticles* / ultrastructure

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Ferric Compounds
  • Magnetite Nanoparticles
  • ferric oxide
  • Chitosan
  • CASP3 protein, human
  • Caspase 3
  • Curcumin

Grants and funding

The authors received no specific funding for this work.