Short Communication: Tracking Tregs: Translocation of CD49b/LAG-3+ Type 1 T Regulatory Cells to the Gut-Associated Lymphoid Tissue of HIV+ Patients

Max Augustin; Carola Horn; Julian Koch; Ute Sandaradura de Silva; Martin Platten; Dirk Nierhoff; Isabelle Suarez; Seung-Hun Chon; Jan Rybniker; Clara Lehmann

doi:10.1089/AID.2018.0052

Short Communication: Tracking Tregs: Translocation of CD49b/LAG-3⁺ Type 1 T Regulatory Cells to the Gut-Associated Lymphoid Tissue of HIV⁺ Patients

AIDS Res Hum Retroviruses. 2019 Mar;35(3):247-250. doi: 10.1089/AID.2018.0052. Epub 2018 Sep 11.

Authors

Max Augustin^{1

2

3}, Carola Horn^{1

2

3}, Julian Koch¹, Ute Sandaradura de Silva², Martin Platten^{1

2}, Dirk Nierhoff⁴, Isabelle Suarez^{1

3}, Seung-Hun Chon⁵, Jan Rybniker^{1

2

3}, Clara Lehmann^{1

2

3}

Affiliations

¹ 1 Division of Infectious Diseases, Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
² 2 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
³ 3 German Center for Infection Research (DZIF), Bonn-Cologne, Germany.
⁴ 4 Clinic for Gastroenterology and Hepatology, University Hospital of Cologne, Cologne, Germany.
⁵ 5 Department of General, Visceral Surgery and Surgical Oncology, University Hospital Cologne, Cologne, Germany.

PMID: 30019612
DOI: 10.1089/AID.2018.0052

Abstract

The gastrointestinal mucosa [gut-associated lymphoid tissue (GALT)] represents the largest site of chronic immune activation and HIV replication. Important cellular agents in the immunopathogenesis of an HIV infection are, in particular, CD49b/LAG-3⁺ type 1 T regulatory cells (Tr1), which secrete large amounts of IL-10 (interleukin-10), and plasmacytoid dendritic cells, the main producers of IFN-α (interferon-alpha). However, the distribution of CD49b/LAG-3⁺ Tr1 cells along the GALT is unknown.

Keywords: GALT; HIV/AIDS; Tr1; immune activation; plasmacytoid dendritic cells; regulatory T cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Anti-Retroviral Agents / therapeutic use
Antigens, CD / metabolism*
Cell Movement / immunology*
Cell Tracking*
Female
HIV Infections / drug therapy
HIV Infections / immunology*
HIV-1 / isolation & purification
Humans
Immunity, Mucosal
Integrin alpha2 / metabolism*
Intestinal Mucosa / immunology*
Intestinal Mucosa / pathology
Lymphocyte Activation Gene 3 Protein
Lymphoid Tissue / immunology*
Lymphoid Tissue / pathology
Male
Middle Aged
T-Lymphocytes, Regulatory / immunology*
Young Adult

Substances

Anti-Retroviral Agents
Antigens, CD
Integrin alpha2
Lymphocyte Activation Gene 3 Protein