Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy

Chembiochem. 2018 Aug 6;19(15):1574-1589. doi: 10.1002/cbic.201800182. Epub 2018 Jul 18.

Abstract

Photodynamic therapy (PDT) is a noninvasive treatment for certain types of cancer, bacterial, fungal and viral infections, and skin diseases. In recent years, adaptation of this treatment so as to achieve more specific targeted cancer therapy in particular has attracted significant attention. We focus herein on the design of novel iridium-based photosensitizers (PSs) with tunable photophysical and photobiological properties as efficient PDT agents. We highlight the ability of some IrIII photosensitizers to target specific cellular components, including their activation by one- and two-photon irradiation.

Keywords: cell imaging; cell organelles; iridium; photodynamic therapy; photosensitizers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology
  • Coordination Complexes / therapeutic use
  • Drug Design*
  • Humans
  • Iridium / chemistry*
  • Iridium / pharmacology*
  • Iridium / therapeutic use
  • Models, Molecular
  • Molecular Targeted Therapy / methods
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Photochemotherapy / methods*
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / pharmacology*
  • Photosensitizing Agents / therapeutic use

Substances

  • Coordination Complexes
  • Photosensitizing Agents
  • Iridium