Abstract
The in vitro activity of anti-pseudomonal β-lactams in combination with avibactam was evaluated against 54 multidrug-resistant non-fermenting Gram-negative bacilli isolated from cystic fibrosis patients. Avibactam increased and/or restored the antibacterial activities of ceftazidime and aztreonam against Pseudomonas aeruginosa and Stenotrophomonas maltophilia, respectively. No β-lactam-avibactam combination was active against Achromobacter xylosoxidans.
Keywords:
Achromobacter; Pseudomonas; Stenotrophomonas; avibactam; cystic fibrosis; β-lactam.
MeSH terms
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Achromobacter denitrificans / drug effects*
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Achromobacter denitrificans / genetics
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Achromobacter denitrificans / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Azabicyclo Compounds / pharmacology*
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Cystic Fibrosis / microbiology*
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Humans
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / isolation & purification
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Stenotrophomonas maltophilia / drug effects*
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Stenotrophomonas maltophilia / genetics
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Stenotrophomonas maltophilia / isolation & purification
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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Azabicyclo Compounds
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beta-Lactams
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avibactam