Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome

Matthew Cowan; Tara Suntum; Andrea D Olivas; Melody Perpich; Mark A Applebaum; Ricardo R Lastra; S Diane Yamada

doi:10.1016/j.gore.2018.06.008

Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome

Gynecol Oncol Rep. 2018 Jun 15:25:94-97. doi: 10.1016/j.gore.2018.06.008. eCollection 2018 Aug.

Authors

Matthew Cowan¹, Tara Suntum², Andrea D Olivas³, Melody Perpich², Mark A Applebaum², Ricardo R Lastra³, S Diane Yamada¹

Affiliations

¹ Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL, USA.
² Department of Pediatrics, Section of Pediatric Hematology/Oncology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL, USA.
³ Department of Pathology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL, USA.

Abstract

•Embryonal rhabdomyosarcoma of the uterine cervix and ovarian Sertoli-Leydig cell tumors are associated with DICER1 mutation•DICER1-associated tumors should prompt genetic counseling and testing•Somatic and germline genetic mutation profiles can be used to differentiate second primary from recurrent tumors.

Keywords: DICER1 syndrome; Embryonal rhabdomyosarcoma; Sertoli-Leydig cell tumor.

Publication types

Case Reports