DNA microarray technology and bioinformatic web services

Acta Microbiol Immunol Hung. 2019 Mar 1;66(1):19-30. doi: 10.1556/030.65.2018.028. Epub 2018 Jul 16.

Abstract

The pan-genomic microarray technique is used for environmental and/or clinical studies. Although microarray is an accurate and sharp diagnostic tool, the expertized bioinformaticians were able to minimize the outcome biases and maximize the flexibility and accuracy of the technique. The knowledge of bioinformatics plays a key role in association with probe designing and the utilization of correct probe sets and platforms. This technique is divided into two parts as dry lab (in silico studies) and wet lab (in vitro studies). Each part covers the other and are known as complementary divisions. In the case of microarray probe designing, a wide range of software, tools, and databases are necessary. Obviously, the application of right databases, software, and tools decreases the probable biases in the outcomes. Due to the importance of suitable probe designing, this article has focused its look onto a variety of online/offline databases, software, and tools.

Keywords: bioinformatics; computational molecular biology; database; microarray.

Publication types

  • Review

MeSH terms

  • Computational Biology / methods*
  • Internet*
  • Microarray Analysis / methods*
  • Oligonucleotide Array Sequence Analysis / methods*
  • Oligonucleotide Probes / genetics

Substances

  • Oligonucleotide Probes