The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis

Yoku Hayakawa; Timothy C Wang

doi:10.1016/j.cell.2018.06.037

The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis

Cell. 2018 Jul 12;174(2):251-253. doi: 10.1016/j.cell.2018.06.037.

Authors

Yoku Hayakawa¹, Timothy C Wang²

Affiliations

¹ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
² Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA. Electronic address: tcw21@columbia.edu.

PMID: 30007413
DOI: 10.1016/j.cell.2018.06.037

Abstract

The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.

Publication types

Comment

MeSH terms

Homeostasis / immunology
Immunity, Innate / immunology*
Interleukin-13 / immunology
Intestine, Small / immunology*
Intestines
Lymphocytes / immunology

Substances

Interleukin-13