The research progress of LncRNA involved in the regulation of inflammatory diseases

Kaili Liao; Jiasheng Xu; Weiming Yang; Xiahong You; Qionghui Zhong; Xiaozhong Wang

doi:10.1016/j.molimm.2018.05.030

The research progress of LncRNA involved in the regulation of inflammatory diseases

Mol Immunol. 2018 Sep:101:182-188. doi: 10.1016/j.molimm.2018.05.030. Epub 2018 Jul 4.

Authors

Kaili Liao¹, Jiasheng Xu², Weiming Yang¹, Xiahong You¹, Qionghui Zhong¹, Xiaozhong Wang³

Affiliations

¹ Department of Clinical Laborotory, The Second Affiliated Hospital of Nanchang University, China; Jiangxi Province Key Laboratory of Laboratory Medicine, China.
² Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, China.
³ Department of Clinical Laborotory, The Second Affiliated Hospital of Nanchang University, China; Jiangxi Province Key Laboratory of Laboratory Medicine, China. Electronic address: wangxzlj@126.com.

PMID: 30007227
DOI: 10.1016/j.molimm.2018.05.030

Abstract

Long non-coding RNA (lncRNA)is a non-coding RNA which lacks a complete open reading frame(ORF) and plays an important role in biological processes such as cell proliferation,differentiation and apoptosis. At present,the expression of lncRNA has been found to be abnormal in inflammatory reaction and inflammatory diseases. It might be involved in the development and progression of inflammatory diseases by regulating the expression of multiple genes and activation of signaling pathways. This article overviewed the progress in study on relationship between lncRNA and inflammatory diseases.

Keywords: Inflammation; Inflammatory bowel diseases; Inflammatory disease; Long non-coding RNA.

Publication types

Review

MeSH terms

Biomedical Research*
Humans
Inflammation / genetics*
Inflammation / pathology
Models, Biological
RNA, Long Noncoding / chemistry
RNA, Long Noncoding / genetics*
RNA, Long Noncoding / metabolism

Substances

RNA, Long Noncoding