Dimethyl fumarate-induced IL-17low IFN-γlow IL-4+ Th cells protect mice from severe encephalomyelitis

Jürgen Brück; Ivana Glocova; Julia Geisel; Christina Kellerer; Martin Röcken; Kamran Ghoreschi

doi:10.1002/eji.201747435

Dimethyl fumarate-induced IL-17^low IFN-γ^low IL-4⁺ Th cells protect mice from severe encephalomyelitis

Eur J Immunol. 2018 Sep;48(9):1588-1591. doi: 10.1002/eji.201747435. Epub 2018 Aug 22.

Authors

Jürgen Brück¹, Ivana Glocova¹, Julia Geisel¹, Christina Kellerer¹, Martin Röcken¹, Kamran Ghoreschi¹

Affiliation

¹ Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.

PMID: 30007005
DOI: 10.1002/eji.201747435

Abstract

Dimethyl fumarate (DMF) promotes an IL-17A^low IFN-γ^low IL-4⁺ CD4⁺ T cell phenotype. Adoptive transfer of in vitro DMF-treated myelin peptide-reactive IL-17A^low IFN-γ^low IL-4⁺ CD4⁺ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF-treated CD4⁺ T cells requires an early in vivo recall.

Keywords: Dimethyl fumarate; EAE; Immunotherapy; T cell vaccine; Th17 cells.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adoptive Transfer
Animals
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / transplantation
Dimethyl Fumarate / pharmacology*
Encephalomyelitis, Autoimmune, Experimental / immunology*
Encephalomyelitis, Autoimmune, Experimental / prevention & control*
Immunosuppressive Agents / pharmacology*
Interferon-gamma / biosynthesis
Interferon-gamma / immunology*
Interleukin-10 / biosynthesis
Interleukin-10 / immunology
Interleukin-17 / biosynthesis
Interleukin-17 / immunology
Interleukin-4 / biosynthesis
Interleukin-4 / immunology*
Mice
Th1 Cells / immunology
Th17 Cells / immunology*
Th2 Cells / immunology

Substances

IFNG protein, mouse
IL10 protein, mouse
Il17a protein, mouse
Immunosuppressive Agents
Interleukin-17
Interleukin-10
Interleukin-4
Interferon-gamma
Dimethyl Fumarate