Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1181-1185. doi: 10.1016/j.bbrc.2018.07.022. Epub 2018 Jul 11.

Abstract

Emerging evidence has supported that TAZ (transcriptional co-activator with PDZ binding motif), one transcription co-activator in Hippo signaling pathway, plays an oncogenic role in liver carcinogenesis. Targeting TAZ could be a potential therapeutic approach for liver cancer patients. In the current study, we aim to determine whether diosgenin could be an inhibitor of TAZ in liver cancer cells. We found that diosgenin inhibited the expression of TAZ in liver cancer cells. Moreover, we found that diosgenin inhibited cell growth, induced apoptosis, suppressed cell migration and invasion in part via inhibition of TAZ in liver cancer cells. Our study provides the evidence to support that diosgenin could be a potential agent for treating human liver cancer.

Keywords: Diosgenin; Hepatocellular carcinoma; Invasion; Migration; Proliferation; TAZ.

MeSH terms

  • Acyltransferases
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Carcinoma, Hepatocellular / genetics*
  • Cell Cycle Checkpoints / drug effects
  • Cell Proliferation / drug effects
  • Diosgenin / chemistry
  • Diosgenin / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms / genetics*
  • Structure-Activity Relationship
  • Transcription Factors / biosynthesis*
  • Transcription Factors / genetics*
  • Wound Healing / drug effects

Substances

  • Antineoplastic Agents
  • Transcription Factors
  • Acyltransferases
  • TAFAZZIN protein, human
  • Diosgenin