No information is available on the clinical use of exenatide during breastfeeding. Because exenatide is a large peptide molecule with a molecular weight of 4187 daltons, the amount in milk is likely to be very low and absorption is unlikely because it is probably partially destroyed in the infant's gastrointestinal tract. It has a short half-life, which might make it a better choice among drugs in this class for nursing mothers. If exenatide is required by the mother, it is not a reason to discontinue breastfeeding. However, until more data become available, exenatide should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.