A case report of purulent pericarditis caused by Candida albicans: Delayed complication forty-years after esophageal surgery

Medicine (Baltimore). 2018 Jul;97(28):e11286. doi: 10.1097/MD.0000000000011286.

Abstract

Rationale: Candida pericarditis is a rare condition with high mortality. Risk factors include thoracic surgery and immunosuppression. We report a case of candida pericarditis which developed forty-years after esophageal reconstruction surgery.

Patient concerns: A 42-year-old female presented with nausea, abdominal discomfort, and chest pain, and was found to have a cardiac tamponade secondary to candida pericarditis. Her notable risk factor was colonic interposition done during her infancy for esophageal atresia.

Diagnoses: The patient underwent emergent pericardial window where 500cc of purulent fluid was drained. The pericardial fluid culture grew Candida albicans.

Interventions: Esophagram did not show any visible leak and the patient improved with surgical drainage and antifungal treatment with Caspofungin. Caspofungin was continued intravenously for a total of four weeks and was switched to fluconazole.

Outcomes: An Echocardiogram performed one month after pericardial window revealed trivial pericardial effusion. Serum beta-D-glucan at the time was negative.

Lessons: This report highlights that candida pericarditis infection could occur as a late complication of colonic interposition. We also demonstrate the utility of using an echinocandin in treating this entity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / administration & dosage
  • Candida albicans / isolation & purification*
  • Caspofungin
  • Colon / transplantation
  • Drainage / methods*
  • Echinocandins / administration & dosage*
  • Esophageal Atresia / surgery*
  • Female
  • Fluconazole / administration & dosage*
  • Humans
  • Lipopeptides / administration & dosage*
  • Long Term Adverse Effects / diagnosis
  • Long Term Adverse Effects / etiology
  • Long Term Adverse Effects / microbiology
  • Mycoses* / diagnosis
  • Mycoses* / etiology
  • Mycoses* / therapy
  • Pericarditis* / diagnosis
  • Pericarditis* / etiology
  • Pericarditis* / microbiology
  • Pericarditis* / therapy
  • Plastic Surgery Procedures / adverse effects*
  • Plastic Surgery Procedures / methods
  • Suppuration / microbiology
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Fluconazole
  • Caspofungin