Economic burden of multidrug-resistant tuberculosis: a multicenter study across Vietnamese regions

Int J Tuberc Lung Dis. 2018 Aug 1;22(8):912-917. doi: 10.5588/ijtld.18.0039.

Abstract

Setting: Multidrug-resistant tuberculosis (MDR-TB) has become a major worldwide health problem. Various studies have been conducted on the cost of MDR-TB treatment; however, this has remained largely unexplored in Viet Nam.

Objective: To estimate the total cost of MDR-TB treatment at several health care facilities in Viet Nam.

Design: A prospective, prevalence-based study was conducted at three selected centers from March to June 2016 in 204 patients, 102 of whom were treated for 9 months and 102 for 20 months. Direct medical costs were calculated using electronic hospital databases, while a questionnaire was used to interview participants for evaluating direct non-medical and indirect costs. Total costs were estimated from a societal perspective in 2017 USD.

Results: Patients were mostly males aged 25-44 years. The average length of hospitalization in the 9-month treatment group was 168 ± 127 days; in the 20-month group, it was 671 ± 119 days. The average treatment cost for MDR-TB was respectively US$1480.34 ± 211.61 and US$2695.58 ± 294.98 for the 9- and 20-month treatment groups. Direct medical costs generally accounted for the highest proportion of the total costs, while the cost of pharmaceuticals and materials comprised the highest direct cost.

Conclusion: There was a significant difference in total costs among the three hospitals in the 9- and 20-month treatment groups.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents / therapeutic use*
  • Cost of Illness
  • Cross-Sectional Studies
  • Databases, Factual
  • Female
  • Health Care Costs / statistics & numerical data*
  • Hospitalization / economics
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Tuberculosis, Multidrug-Resistant / drug therapy*
  • Tuberculosis, Multidrug-Resistant / economics*
  • Tuberculosis, Multidrug-Resistant / epidemiology
  • Vietnam / epidemiology
  • Young Adult

Substances

  • Antitubercular Agents