Effect of spatial light distribution on the thermal response of vascular tissue

Biomed Opt Express. 2018 Jun 8;9(7):3037-3048. doi: 10.1364/BOE.9.003037. eCollection 2018 Jul 1.

Abstract

The aim of the current study is to investigate the effect of radial and cylindrical light distributions on the response of vascular tissue during 1470-nm irradiation in ex vivo models. Due to a low irradiance (5.3 W/cm2) and wide light distribution, cylindrically diffusing irradiation yielded uniform thermal coagulation while radial irradiation accompanied delamination of layers in leporine veins. Bovine foot model testing verified that the diffusing irradiation was associated with the steady maximum temperature and no tissue attachment, compared with the radial irradiation. The proposed cylindrical light application can be a feasible way to treat varicose veins in an effective manner.

Keywords: (120.6810) Thermal effects; (140.3390) Laser materials processing; (170.1610) Clinical applications; (170.3660) Light propagation in tissues; (230.1980) Diffusers.