Tumor-selective catalytic nanosystem for activatable theranostics

Chem Commun (Camb). 2018 Jul 19;54(59):8214-8217. doi: 10.1039/c8cc03922d.

Abstract

A novel tumor-selective catalytic nanosystem that enables efficient chemodynamic therapy (CDT) and activatable fluorescence imaging in H2O2-rich tumor microenvironments has been developed.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • DNA Probes / chemistry
  • Fluorescence
  • Fluorescent Dyes / chemistry
  • Graphite / chemistry
  • HeLa Cells
  • Hepatocytes / drug effects
  • Humans
  • Hydrogen Peroxide / analysis
  • Metal Nanoparticles / chemistry*
  • Microscopy, Confocal
  • Microscopy, Fluorescence
  • Neoplasms / diagnostic imaging*
  • Oxides / chemistry
  • Rhodamines / chemistry
  • Silver / chemistry
  • Theranostic Nanomedicine*

Substances

  • 5-carboxytetramethylrhodamine succinimidyl ester
  • Antineoplastic Agents
  • DNA Probes
  • Fluorescent Dyes
  • Oxides
  • Rhodamines
  • Silver
  • Graphite
  • Hydrogen Peroxide