Enrichment of protein therapeutics and biomarkers for LC-MS quantification

Bioanalysis. 2018 Jul 1;10(13):979-982. doi: 10.4155/bio-2018-0056. Epub 2018 Jul 4.

Authors

Jie Pu^{1

2}, Bo An^{1

2}, Faye Vazvaei³, Jun Qu^{1

2}

Affiliations

¹ Department of Pharmaceutical Sciences, School of Pharmacy & Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
² New York State Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY 14203, USA.
³ Roche Pharmaceutical Research & Early Development, Roche Innovation Center New York, New York, NY 10016, USA.

PMID: 29972308
DOI: 10.4155/bio-2018-0056

No abstract available

Keywords: LC–MS; antibody; biotherapeutics; enrichment; immunoassay; pharmacokinetics; protein quantification; sensitivity.

Publication types

Editorial

MeSH terms

Biomarkers / analysis
Biomarkers / chemistry
Chromatography, Liquid / methods*
Immunoassay
Proteins / analysis*
Proteins / chemistry*
Proteins / isolation & purification
Proteins / therapeutic use
Solid Phase Extraction
Tandem Mass Spectrometry / methods*

Substances

Biomarkers
Proteins