Suicidal ideation in patients with coronary heart disease and hypertension: Baseline results from the DEPSCREEN-INFO clinical trial

Clin Psychol Psychother. 2018 Nov;25(6):754-764. doi: 10.1002/cpp.2305. Epub 2018 Jul 3.

Abstract

Background: A high proportion of cardiac patients suffers from depression, which is an antecedent for suicidal ideation. This study identifies clinical vulnerabilities for suicidal ideation in cardiac patients.

Methods: The primary outcome of the study was severity of suicidal ideation as measured with the Patient Health Questionnaire (PHQ-9) item No. 9. Covariates were demographics, cardiac characteristics (i.e., Canadian Cardiovascular Society angina rating of chest pain and New York Heart Association rating of shortness of breath), depression (PHQ-8,i.e., PHQ-9 minus item No. 9), anxiety (Generalized Anxiety Disorder-7, GAD-7), somatic symptoms (PHQ-15), illness perception (Brief-Illness Perception Questionnaire), and health-related quality of life (EuroQol-5D, EQ 5D).

Results: Data from 1,976 patients were analysed. At least 14% (95% CI [12%, 16%]) of patients indicated suicidal ideations within the last 2 weeks. Bivariate analyses yielded associations between suicidal ideation and higher levels of depression severity, anxiety severity, somatic symptom burden, chest pain, shortness of breath, negative illness perceptions, reduced health-related quality of life, and a higher probability of living alone (all p < 0.001). A multivariable ordinal regression revealed depression severity and anxiety severity to show the highest associations with suicidal ideation (ORPHQ-8 = 1.22, p < 0.001; ORGAD-7 = 1.09, p < 0.001). Having a defibrillator implant was associated with a lower probability of suicidal ideation (OR = 0.27, p = 0.017).

Conclusions: This study identified several clinical vulnerabilities of suicidal ideation. The results stress the importance of screening for suicidal ideation in clinical practice.

Keywords: coronary heart disease; depressive disorder; hypertension; prognosis; suicidal ideation; vulnerability.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Comorbidity
  • Coronary Disease / epidemiology*
  • Coronary Disease / psychology
  • Cross-Sectional Studies
  • Depressive Disorder / diagnosis*
  • Depressive Disorder / epidemiology*
  • Depressive Disorder / psychology
  • Female
  • Germany / epidemiology
  • Humans
  • Hypertension / epidemiology*
  • Hypertension / psychology
  • Male
  • Prevalence
  • Risk Factors
  • Severity of Illness Index
  • Suicidal Ideation*
  • Surveys and Questionnaires*