Right filter-selection for phase separation in equilibrium solubility measurement

Eur J Pharm Sci. 2018 Oct 15:123:98-105. doi: 10.1016/j.ejps.2018.06.031. Epub 2018 Jun 30.

Authors

Gergely Völgyi¹, Dóra Csicsák¹, Krisztina Takács-Novák²

Affiliations

¹ Semmelweis University, Department of Pharmaceutical Chemistry, Hőgyes E. u. 9, H-1092 Budapest, Hungary.
² Semmelweis University, Department of Pharmaceutical Chemistry, Hőgyes E. u. 9, H-1092 Budapest, Hungary. Electronic address: novak.krisztina@pharma.semmelweis-univ.hu.

PMID: 29969669
DOI: 10.1016/j.ejps.2018.06.031

No abstract available

Keywords: Equilibrium solubility; Filtration; Ionizable drugs; Phase separation; Sedimentation; Shake-flask method.

MeSH terms

Chemistry Techniques, Analytical / instrumentation
Chemistry Techniques, Analytical / methods*
Chemistry, Pharmaceutical
Diclofenac / chemistry
Diclofenac / isolation & purification
Filtration / instrumentation
Filtration / methods*
Hydrochlorothiazide / chemistry
Hydrochlorothiazide / isolation & purification
Hydrogen-Ion Concentration
Kinetics
Membranes, Artificial*
Papaverine / chemistry
Papaverine / isolation & purification
Progesterone / chemistry
Progesterone / isolation & purification
Solubility

Substances

Membranes, Artificial
Hydrochlorothiazide
Diclofenac
Progesterone
Papaverine