Radiation therapy in renal cell carcinoma

Francesca De Felice; Vincenzo Tombolini

doi:10.1016/j.critrevonc.2018.06.002

Radiation therapy in renal cell carcinoma

Crit Rev Oncol Hematol. 2018 Aug:128:82-87. doi: 10.1016/j.critrevonc.2018.06.002. Epub 2018 Jun 12.

Authors

Francesca De Felice¹, Vincenzo Tombolini²

Affiliations

¹ Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy. Electronic address: francesca.defelice@uniroma1.it.
² Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

PMID: 29958634
DOI: 10.1016/j.critrevonc.2018.06.002

Abstract

Renal cell carcinoma (RCC) is classically regarded as extremely resistant to classical fractionated radiation therapy (RT). Nowadays, there is convincing data supporting RCC radiosensitivity to high fraction doses, which may represent an ideal issue for new treatment strategies in primary and oligometastatic RCC disease. This review discusses the role of RT in RCC and its potential therapeutic scenario focusing on the most interesting clinical trials.

Keywords: Ceramide; Oligometastasis; Radioresistance; Radiosensitivity; Radiosurgery; Radiotherapy; Renal cell carcinoma; Stereotactic; kidney.

Publication types

Review

MeSH terms

Animals
Carcinoma, Renal Cell / radiotherapy*
Humans
Kidney Neoplasms / radiotherapy*
Radiation Dose Hypofractionation*
Treatment Outcome