For T Cells, the Child Is Father of the Man

Kristin A Hogquist; Sara E Hamilton

doi:10.1016/j.cell.2018.06.015

For T Cells, the Child Is Father of the Man

Cell. 2018 Jun 28;174(1):16-18. doi: 10.1016/j.cell.2018.06.015.

Authors

Kristin A Hogquist¹, Sara E Hamilton²

Affiliations

¹ Department of Laboratory Medicine & Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. Electronic address: hogqu001@umn.edu.
² Department of Laboratory Medicine & Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA.

PMID: 29958105
DOI: 10.1016/j.cell.2018.06.015

Abstract

When T cells respond to infectious agents, they differentiate into effector and memory cells. In this issue of Cell, Smith et al. use a genetic "time-stamping" method to show that the developmental time the T cell arises-near birth or as an adult-dictates what type of T effector or memory cell results.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes
Child
Genes, Developmental*
Humans
Immunologic Memory*
T-Lymphocytes