Abstract
Obesity is fast becoming a major disorder for mankind. Numerous lifestyle factors play a role in the rising obesity epidemic, including changes in the diet and the lack of physical activity. Unfortunately, more than two-thirds of the adult population in developed countries is considered overweight and more than a third of them are obese. In addition to the well-publicized association of obesity with type II diabetes and cardiovascular diseases, emerging evidence indicates that obesity represents a major risk factor for fatty liver diseases and fatty liver disease-associated hepatocellular carcinoma (HCC).
Keywords:
Hepatocellular carcinoma; Microbiota; Non-alcoholic steatohepatitis; Obesity; Therapy.
Publication types
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Introductory Journal Article
MeSH terms
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Animals
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Carcinoma, Hepatocellular* / epidemiology
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Carcinoma, Hepatocellular* / etiology
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Carcinoma, Hepatocellular* / metabolism
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Carcinoma, Hepatocellular* / pathology
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Cardiovascular Diseases* / epidemiology
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Cardiovascular Diseases* / metabolism
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Cardiovascular Diseases* / pathology
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Diabetes Complications* / epidemiology
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Diabetes Complications* / metabolism
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Diabetes Complications* / pathology
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Diabetes Mellitus, Type 2* / epidemiology
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Diabetes Mellitus, Type 2* / metabolism
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Diabetes Mellitus, Type 2* / pathology
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Fatty Liver* / epidemiology
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Fatty Liver* / metabolism
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Fatty Liver* / pathology
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Humans
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Liver Neoplasms* / epidemiology
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Liver Neoplasms* / etiology
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Liver Neoplasms* / metabolism
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Liver Neoplasms* / pathology
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Obesity* / complications
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Obesity* / epidemiology
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Obesity* / metabolism
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Obesity* / pathology