Angiogenesis and Hepatic Fibrosis: Western and Chinese Medicine Therapies on the Road

Chin J Integr Med. 2018 Sep;24(9):713-720. doi: 10.1007/s11655-018-3007-1. Epub 2018 Jun 25.

Abstract

Hepatic fibrosis is a common feature of almost all chronic liver diseases. Formation of new vessels (angiogenesis) is a process strictly related to the progressive fibrogenesis which leads to cirrhosis and liver cancer. This review mainly concerns the relationship between angiogenesis and hepatic fibrosis, by considering the mechanism of angiogenesis, cells in angiogenesis, anti-angiogenic and Chinese medicine therapies.

Keywords: Chinese medicine; angiogenesis; hepatic fibrosis; review.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Drugs, Chinese Herbal / therapeutic use*
  • Hepatic Stellate Cells / drug effects
  • Humans
  • Liver Cirrhosis / drug therapy*
  • Liver Cirrhosis / etiology
  • Medicine, Chinese Traditional*
  • Neovascularization, Pathologic / complications*
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Vascular Endothelial Growth Factor A / physiology

Substances

  • Angiogenesis Inhibitors
  • Drugs, Chinese Herbal
  • Vascular Endothelial Growth Factor A