It is a particularly challenging task in stereochemistry to determine the absolute configuration of chiral molecules, i.e. to assign to a given sample the microscopic enantiomeric structure. In recent years, Coulomb Explosion Imaging (CEI) has been shown to yield directly the absolute configuration of small molecules in the gas phase. This contribution describes the experimental basics of this approach, highlights the most significant results and discusses limitations. A short discussion on extending Coulomb Explosion Imaging beyond analytic aspects to fundamental questions of molecular chirality concludes this review.