A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery

J Surg Oncol. 2018 Aug;118(2):283-300. doi: 10.1002/jso.25105. Epub 2018 Jun 24.

Abstract

Near-infrared (NIR) fluorescence imaging is gaining clinical acceptance over the last years and has been used for detection of lymph nodes, several tumor types, vital structures and tissue perfusion. This review focuses on NIR fluorescence imaging with indocyanine green and methylene blue for different clinical applications in abdominal surgery with an emphasis on oncology, based on a systematic literature search. Furthermore, practical information on doses, injection times, and intraoperative use are provided.

Keywords: image-guided surgery; near-infrared; oncology; optical imaging; tumor.

Publication types

  • Review

MeSH terms

  • Abdomen / diagnostic imaging
  • Abdomen / surgery
  • Abdominal Neoplasms / diagnostic imaging*
  • Abdominal Neoplasms / surgery*
  • Coloring Agents
  • Humans
  • Indocyanine Green*
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / pathology
  • Methylene Blue*
  • Optical Imaging / methods*
  • Sentinel Lymph Node Biopsy / methods
  • Surgery, Computer-Assisted / methods*

Substances

  • Coloring Agents
  • Indocyanine Green
  • Methylene Blue