HDAC6 at Crossroads of Infection and Innate Immunity

Trends Immunol. 2018 Aug;39(8):591-595. doi: 10.1016/j.it.2018.05.004. Epub 2018 Jun 21.

Abstract

Histone deacetylase 6 (HDAC6) acts by enzyme-dependent and -independent mechanisms to regulate diverse cellular processes including autophagy, the ubiquitin proteasome system, and cell migration. HDAC6 also has emerging roles in innate immunity, including pathogen sensing and destruction, thus placing this enzyme at the crossroads of infection and innate immunity.

Keywords: HDAC6; autophagy; bacterial and viral infection; deacetylase; inflammation; innate immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy
  • Histone Deacetylase 6 / genetics
  • Histone Deacetylase 6 / metabolism*
  • Humans
  • Immunity, Innate
  • Infections / immunology*
  • Pathogen-Associated Molecular Pattern Molecules / immunology
  • Proteasome Endopeptidase Complex / metabolism*
  • Receptors, Pattern Recognition / metabolism
  • Signal Transduction

Substances

  • Pathogen-Associated Molecular Pattern Molecules
  • Receptors, Pattern Recognition
  • Proteasome Endopeptidase Complex
  • HDAC6 protein, human
  • Histone Deacetylase 6