Abstract
ARL11 is a tumor suppressor gene with established pro-apoptotic properties, but its function beyond this role is poorly understood. A new analysis of macrophage activation has identified ARL11 as a novel regulator of a mitogen-activated protein kinase (MAPK). These findings expand on the function of ARL11 beyond its tumor suppressor activity and highlight a novel role as a regulator of macrophage activation and inflammatory response.
© 2018 Platko et al.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
ADP-Ribosylation Factors / genetics
-
ADP-Ribosylation Factors / metabolism*
-
Extracellular Signal-Regulated MAP Kinases / genetics
-
Extracellular Signal-Regulated MAP Kinases / metabolism*
-
Humans
-
Lipopolysaccharides / pharmacology*
-
Macrophage Activation / drug effects*
-
Macrophages / drug effects
-
Macrophages / enzymology*
-
Phosphorylation
-
Signal Transduction
-
p38 Mitogen-Activated Protein Kinases / genetics
-
p38 Mitogen-Activated Protein Kinases / metabolism*
Substances
-
Lipopolysaccharides
-
Extracellular Signal-Regulated MAP Kinases
-
p38 Mitogen-Activated Protein Kinases
-
ADP-Ribosylation Factors
-
ARL11 protein, human