MAPping the kinase landscape of macrophage activation

J Biol Chem. 2018 Jun 22;293(25):9910-9911. doi: 10.1074/jbc.H118.003380.

Abstract

ARL11 is a tumor suppressor gene with established pro-apoptotic properties, but its function beyond this role is poorly understood. A new analysis of macrophage activation has identified ARL11 as a novel regulator of a mitogen-activated protein kinase (MAPK). These findings expand on the function of ARL11 beyond its tumor suppressor activity and highlight a novel role as a regulator of macrophage activation and inflammatory response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADP-Ribosylation Factors / genetics
  • ADP-Ribosylation Factors / metabolism*
  • Extracellular Signal-Regulated MAP Kinases / genetics
  • Extracellular Signal-Regulated MAP Kinases / metabolism*
  • Humans
  • Lipopolysaccharides / pharmacology*
  • Macrophage Activation / drug effects*
  • Macrophages / drug effects
  • Macrophages / enzymology*
  • Phosphorylation
  • Signal Transduction
  • p38 Mitogen-Activated Protein Kinases / genetics
  • p38 Mitogen-Activated Protein Kinases / metabolism*

Substances

  • Lipopolysaccharides
  • Extracellular Signal-Regulated MAP Kinases
  • p38 Mitogen-Activated Protein Kinases
  • ADP-Ribosylation Factors
  • ARL11 protein, human

Grants and funding