Manual Mobilization of Subcutaneous Fibrosis in Mice

Mariane Altomare; Andréa Monte-Alto-Costa

doi:10.1016/j.jmpt.2017.10.011

Manual Mobilization of Subcutaneous Fibrosis in Mice

J Manipulative Physiol Ther. 2018 Jun;41(5):359-362. doi: 10.1016/j.jmpt.2017.10.011. Epub 2018 Jun 20.

Authors

Mariane Altomare¹, Andréa Monte-Alto-Costa²

Affiliations

¹ Tissue Repair Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil.
² Tissue Repair Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: amacosta.uerj@gmail.com.

PMID: 29933891
DOI: 10.1016/j.jmpt.2017.10.011

Abstract

Objective: The aim of this study was to induce the remodeling of subcutaneous fibrosis in mice by the manual mobilization of skin and subcutaneous tissue.

Methods: Seven days after the induction of subcutaneous fibrosis, mice were divided into 3 groups: control, stretch, and manual mobilization. Stretch was achieved by elongating the trunk, and manual mobilization was achieved by using the indicator fingertip of both hands, side by side, touching the back and performing a brief stretch. Stretch or manual mobilization was performed once a day for 7 days.

Results: Fibrosis was present in the subcutaneous tissue of control animals, whereas brief stretch and manual mobilization were found to reduce fibrosis.

Conclusions: Mechanical stimulation through manual mobilization, or brief stretching, reduced subcutaneous fibrosis after tissue injury.

Keywords: Extracellular Matrix; Fibrosis; Mice; Musculoskeletal Manipulations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Connective Tissue / pathology*
Female
Fibrosis / therapy*
Male
Mice
Muscle Strength / physiology
Musculoskeletal Manipulations / methods*