A reversible carnitine palmitoyltransferase (CPT1) inhibitor offsets the proliferation of chronic lymphocytic leukemia cells

Haematologica. 2018 Nov;103(11):e531-e536. doi: 10.3324/haematol.2017.175414. Epub 2018 Jun 21.

Authors

Elena Gugiatti¹, Claudya Tenca¹, Silvia Ravera², Marina Fabbi³, Fabio Ghiotto^{1

4}, Andrea N Mazzarello⁵, Davide Bagnara^{1

5}, Daniele Reverberi⁴, Daniela Zarcone¹, Giovanna Cutrona⁴, Adalberto Ibatici⁶, Ermanno Ciccone¹, Zbigniew Darzynkiewicz⁷, Franco Fais^{1

4}, Silvia Bruno⁸

Affiliations

¹ Department of Experimental Medicine, University of Genoa, Italy.
² Department of Pharmacy, University of Genoa, Italy.
³ Biotherapies Unit, Ospedale Policlinico San Martino, Genoa, Italy.
⁴ Molecular Pathology Unit, Ospedale Policlinico San Martino, Genoa, Italy.
⁵ The Feinstein Institute for Medical Research, North Shore-Long Island, Experimental Immunology, Manhasset, NY, USA.
⁶ Hematology Unit and Bone Marrow Transplantation, Ospedale Policlinico San Martino, Genoa, Italy.
⁷ Brander Cancer Research Institute, Department of Pathology, New York Medical College, NY, USA.
⁸ Department of Experimental Medicine, University of Genoa, Italy silvia.bruno@unige.it.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

A549 Cells
Carnitine O-Palmitoyltransferase / antagonists & inhibitors*
Carnitine O-Palmitoyltransferase / genetics
Carnitine O-Palmitoyltransferase / metabolism
Cell Proliferation / drug effects*
Enzyme Inhibitors / pharmacology*
HCT116 Cells
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / enzymology
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
MCF-7 Cells
Neoplasm Proteins / antagonists & inhibitors*
Neoplasm Proteins / genetics
Neoplasm Proteins / metabolism
PC-3 Cells

Substances

Enzyme Inhibitors
Neoplasm Proteins
Carnitine O-Palmitoyltransferase