Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits

Karem H Alzoubi; Zuhair Bani Ismail; Mohamed K Al-Essa; Osama Y Alshogran; Reem F Abutayeh; Nareman Abu-Baker

doi:10.2147/CPAA.S167150

Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits

Clin Pharmacol. 2018 Jun 12:10:73-78. doi: 10.2147/CPAA.S167150. eCollection 2018.

Authors

Karem H Alzoubi¹, Zuhair Bani Ismail², Mohamed K Al-Essa³, Osama Y Alshogran¹, Reem F Abutayeh⁴, Nareman Abu-Baker⁵

Affiliations

¹ Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
² Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan.
³ Department of Physiology, Faculty of Medicine, University of Jordan, Amman, Jordan.
⁴ Department of Medicinal Chemistry and Phytochemistry, Applied Science Private University, Amman, Jordan.
⁵ Philadelphia Biomedical Products Development Center, Amman, Jordan.

Abstract

Introduction: This study explored D-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits.

Materials and methods: D-ribose was administered once as 420 mg/kg (N=4) or 840 mg/kg (N=6) dose intravenously, or as an oral dose of 420 mg/kg (N=3) or 840 mg/kg (N=3). Serum was obtained at various time points, up to 210 minutes after administration. Urine was also collected after IV administration. Pharmacokinetic parameters were determined from drug concentration-time data using Kinetica software.

Results: The findings showed that D-ribose follows a dose-dependent kinetic profile. With doubling the IV dose, AUC_total was significantly increased by threefold, while the clearance was decreased by 44%. The half-life was 1.7-fold longer at the higher dose. Similar nonsignificant trends were also observed at oral administration. D-ribose was rapidly absorbed (T_max=36-44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18-37.5%) recovered from urine.

Conclusion: Collectively, D-ribose showed a dose-dependent kinetic profile, where parameters change according to dosing levels. D-ribose clearance seems to follow first-order kinetics at low dose. Thereafter, elimination systems are saturated, and elimination continues in a fast manner. Urine recovery was partial, which could be attributed to the several metabolic pathways that pentose can undergo.

Keywords: D-ribose; intravenous; oral; pharmacokinetics; rabbits; single dose.