MRI to Assess Neurological Function

Brian J Nieman; Matthijs C van Eede; Shoshana Spring; Jun Dazai; R Mark Henkelman; Jason P Lerch

doi:10.1002/cpmo.44

MRI to Assess Neurological Function

Curr Protoc Mouse Biol. 2018 Jun;8(2):e44. doi: 10.1002/cpmo.44. Epub 2018 May 22.

Authors

Brian J Nieman^{1

2}, Matthijs C van Eede¹, Shoshana Spring¹, Jun Dazai¹, R Mark Henkelman^{1

2}, Jason P Lerch^{1

2

3}

Affiliations

¹ Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
² Department of Medical Biophysics, The University of Toronto, Toronto, Ontario, Canada.
³ Corresponding author: jason.lerch@sickkids.ca.

PMID: 29927554
DOI: 10.1002/cpmo.44

Abstract

This article describes a detailed set of protocols for mouse brain imaging using MRI. We focus primarily on measuring changes in neuroanatomy, and provide both instructions for mouse preparation and details on image acquisition, image processing, and statistics. Practical details as well as theoretical considerations are provided. © 2018 by John Wiley & Sons, Inc.

Keywords: MRI; image processing; neuroscience; statistics.

MeSH terms

Animals
Brain / anatomy & histology
Brain / diagnostic imaging*
Female
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Mice / anatomy & histology*