Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle

Chem Commun (Camb). 2018 Jul 5;54(55):7617-7620. doi: 10.1039/c8cc01601a.

Abstract

A nano metal-organic-framework (nanoMOF) was employed as a first-of-its kind drug delivery vehicle (DDV) for the photo-controlled release of therapeutics with simultaneous breakdown of the carrier into small molecules.

MeSH terms

  • Adsorption
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Azo Compounds / chemistry
  • Azo Compounds / radiation effects
  • Azo Compounds / toxicity
  • Blood Proteins / chemistry
  • Cattle
  • Drug Carriers / chemistry
  • Drug Carriers / radiation effects*
  • Drug Carriers / toxicity
  • Fluorouracil / chemistry
  • Fluorouracil / pharmacology*
  • Humans
  • MCF-7 Cells
  • Metal-Organic Frameworks / chemistry
  • Metal-Organic Frameworks / radiation effects*
  • Metal-Organic Frameworks / toxicity
  • Mice
  • Nanoparticles / chemistry
  • Nanoparticles / radiation effects*
  • Nanoparticles / toxicity
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / toxicity
  • Porosity
  • Ultraviolet Rays

Substances

  • Antineoplastic Agents
  • Azo Compounds
  • Blood Proteins
  • Drug Carriers
  • Metal-Organic Frameworks
  • Polyethylene Glycols
  • Fluorouracil