Abstract
BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.
MeSH terms
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Adaptor Proteins, Signal Transducing / antagonists & inhibitors*
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Adaptor Proteins, Signal Transducing / chemistry
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Adaptor Proteins, Signal Transducing / metabolism*
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Apoptosis Regulatory Proteins / antagonists & inhibitors*
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Apoptosis Regulatory Proteins / chemistry
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Apoptosis Regulatory Proteins / metabolism*
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Cell Line, Tumor
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HSP70 Heat-Shock Proteins / antagonists & inhibitors
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HSP70 Heat-Shock Proteins / chemistry
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HSP70 Heat-Shock Proteins / metabolism
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Humans
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Molecular Docking Simulation
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Protein Binding
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Protein Multimerization / drug effects
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Thiazolidinediones / chemical synthesis
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Thiazolidinediones / chemistry
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Thiazolidinediones / metabolism*
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Thiazolidinediones / pharmacology*
Substances
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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BAG3 protein, human
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HSP70 Heat-Shock Proteins
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Thiazolidinediones