[Molecular mechanisms of anti-inflammatory action of AMPK]

Sheng Li Xue Bao. 2018 Jun 25;70(3):329-334.
[Article in Chinese]

Abstract

AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, is known as the "cellular energy regulator" and a key molecule to maintain the energy balance of cells and organism. Recent studies have shown that AMPK exerts anti-inflammatory effects mainly through activating SIRT1, PGC-1α, p53, FoxO3a and p300, and down-regulating the activity of various inflammatory related proteins such as NF-κB and AP-1. This article reviews the molecular mechanisms of the anti- inflammatory effects of AMPK, and provides some clues for the development of AMPK-targeted therapeutics to treat inflammation and related diseases.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • E1A-Associated p300 Protein
  • Energy Metabolism*
  • Forkhead Box Protein O3
  • Humans
  • Inflammation / metabolism*
  • NF-kappa B
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Sirtuin 1
  • Tumor Suppressor Protein p53

Substances

  • FOXO3 protein, human
  • Forkhead Box Protein O3
  • NF-kappa B
  • PPARGC1A protein, human
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • E1A-Associated p300 Protein
  • EP300 protein, human
  • AMP-Activated Protein Kinases
  • SIRT1 protein, human
  • Sirtuin 1