Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo

Bull Exp Biol Med. 2018 Jun;165(2):248-251. doi: 10.1007/s10517-018-4140-8. Epub 2018 Jun 19.

Abstract

Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Four intranasal doses of OD40min, OD40max, and OD70min and one intranasal dose of OD70max before infection of BALB/c mice with A(H1N1)pdm09 influenza virus significantly reduced mortality and prolonged life span in comparison with controls receiving saline. These and our previous data attest to clear-cut preventive effect of OD in influenza infection.

Keywords: antiviral efficiency; influenza virus; oxidized dextran.

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Dextrans / chemistry
  • Dextrans / pharmacology*
  • Dextrans / therapeutic use
  • Dogs
  • Female
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Madin Darby Canine Kidney Cells
  • Male
  • Mice
  • Mice, Inbred BALB C / abnormalities
  • Orthomyxoviridae Infections / prevention & control*
  • Oxidation-Reduction

Substances

  • Antiviral Agents
  • Dextrans