An analysis of cognitive functioning of children and youth with type 1 diabetes (T1DM) in the context of glycemic control

Eur Rev Med Pharmacol Sci. 2018 Jun;22(11):3453-3460. doi: 10.26355/eurrev_201806_15170.

Abstract

Objective: The aim of the study was to evaluate the cognitive functioning of children and youth with type 1 diabetes (T1DM).

Patients and methods: The study included 68 children with type 1 diabetes, aged 6-17 years, divided into 3 groups according to the level of glycated hemoglobin (HbA1c): group 1: HbA1c ≤ 6.0-7.5%; group 2: HbA1c 7.6-8.5%; group 3: HbA1c over 8.6%. Wechsler's intelligence scale (WISC-R), the Trail of 10 words and Brickenkamp's and Zillmer's d2 Test of Attention were used to assess cognitive functioning.

Results: The research demonstrated a significant influence of low, medium or high glycaemic control on lowering the general level of functioning in verbal intelligence, and in WISC-R subtests: information, vocabulary, comprehension, number sequencing and block design.

Conclusions: Children with type 1 diabetes mellitus can experience difficulties in cognitive functioning, as a consequence of high HbA1c. Additional research, involving a larger group of patients and a wider age range when the disease was diagnosed, will enable further findings on the occurrence of cognitive impairment in T1DM.

MeSH terms

  • Adolescent
  • Child
  • Cognition*
  • Diabetes Mellitus, Type 1 / metabolism*
  • Diabetes Mellitus, Type 1 / psychology*
  • Female
  • Glycated Hemoglobin / metabolism*
  • Humans
  • Male
  • Psychological Tests / statistics & numerical data

Substances

  • Glycated Hemoglobin A