MRI and luminescence detection of Zn2+ with a lanthanide complex-zinc finger peptide conjugate

Chem Commun (Camb). 2018 Jun 28;54(53):7350-7353. doi: 10.1039/c8cc04366c.

Abstract

A bioinspired probe based on a zinc finger peptide functionalized by a lanthanide(iii)-DOTA monoamide complex turns out to be active for both luminescence and MRI detection of Zn2+, depending on the lanthanide cation. A mechanism for MRI-based detection is proposed.

MeSH terms

  • Lanthanoid Series Elements / chemistry*
  • Luminescence*
  • Magnetic Resonance Imaging*
  • Molecular Probes / chemistry*
  • Organometallic Compounds / chemistry*
  • Peptides / chemistry*
  • Zinc / analysis*
  • Zinc Fingers

Substances

  • Lanthanoid Series Elements
  • Molecular Probes
  • Organometallic Compounds
  • Peptides
  • Zinc