CRISPR-Cas13a: Prospects for Plant Virus Resistance

Muhammad Zuhaib Khan; Imran Amin; Amir Hameed; Shahid Mansoor

doi:10.1016/j.tibtech.2018.05.005

CRISPR-Cas13a: Prospects for Plant Virus Resistance

Trends Biotechnol. 2018 Dec;36(12):1207-1210. doi: 10.1016/j.tibtech.2018.05.005. Epub 2018 Jun 11.

Authors

Muhammad Zuhaib Khan¹, Imran Amin², Amir Hameed³, Shahid Mansoor⁴

Affiliations

¹ National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan. Electronic address: mzuhaibkhan@nibge.org.
² National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan. Electronic address: imran@nibge.org.
³ Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan. Electronic address: amirhameed@gcuf.org.pk.
⁴ National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan. Electronic address: smansoor@nibge.org.

PMID: 29903474
DOI: 10.1016/j.tibtech.2018.05.005

Abstract

CRISPR-Cas13a is an efficient RNA targeting and editing tool characterized recently in prokaryotes. This system can be recruited to engineer resistance against plant RNA viruses and regulate gene expression. We discuss some important achievements in using the CRISPR-Cas13a system to confer resistance against plant RNA viruses.

Keywords: CRISPR–Cas13a; RNA editing; RNA interference; RNA virus.

Publication types

Review

MeSH terms

CRISPR-Cas Systems*
Disease Resistance*
Gene Editing / methods*
Plant Diseases / prevention & control*
Plant Viruses / growth & development
Plant Viruses / immunology*
Plants, Genetically Modified / immunology*
Plants, Genetically Modified / virology
RNA Viruses / growth & development
RNA Viruses / immunology*