Prostaglandins in the pathogenesis of kidney diseases

Yuanyuan Li; Weiwei Xia; Fei Zhao; Zhaoying Wen; Aihua Zhang; Songming Huang; Zhanjun Jia; Yue Zhang

doi:10.18632/oncotarget.25005

Prostaglandins in the pathogenesis of kidney diseases

Oncotarget. 2018 May 29;9(41):26586-26602. doi: 10.18632/oncotarget.25005.

Authors

Yuanyuan Li^{1

2

3}, Weiwei Xia^{1

2

3}, Fei Zhao^{1

2

3}, Zhaoying Wen³, Aihua Zhang^{1

2

3}, Songming Huang^{1

2

3}, Zhanjun Jia^{1

2

3}, Yue Zhang^{1

2

3}

Affiliations

¹ Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
² Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing 210029, China.
³ Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.

Abstract

Prostaglandins (PGs) are important lipid mediators produced from arachidonic acid via the sequential catalyzation of cyclooxygenases (COXs) and specific prostaglandin synthases. There are five subtypes of PGs, namely PGE2, PGI2, PGD2, PGF2α, and thromboxane A2 (TXA2). PGs exert distinct roles by combining to a diverse family of membrane-spanning G protein-coupled prostanoid receptors. The distribution of these PGs, their specific synthases and receptors vary a lot in the kidney. This review summarized the recent findings of PGs together with the COXs and their specific synthases and receptors in regulating renal function and highlighted the insights into their roles in the pathogenesis of various kidney diseases.

Keywords: acute kidney injury; chronic kidney injury; kidney; prostaglandins.

Publication types

Review