Immunomodulatory vasoactive intestinal peptide amphiphile micelles

Biomater Sci. 2018 Jun 25;6(7):1717-1722. doi: 10.1039/c8bm00466h.

Abstract

Two different vasoactive intestinal peptide (VIP) amphiphiles have been formulated which readily form micelles of varying shapes. Interestingly, VIP micelle structure has been found to directly correlate to anti-inflammatory behavior providing evidence that these biomaterials can serve as a promising new therapeutic modality.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • B7-2 Antigen / genetics
  • B7-2 Antigen / immunology
  • Cells, Cultured
  • Chemokine CCL22 / genetics
  • Chemokine CCL22 / immunology
  • Dendritic Cells / cytology
  • Dendritic Cells / drug effects*
  • Dendritic Cells / immunology
  • Gene Expression
  • Humans
  • Immunologic Factors / pharmacology*
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology
  • Macrophages / cytology
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Mice
  • Micelles
  • Protein Structure, Secondary
  • Surface-Active Agents / chemistry
  • T-Lymphocytes, Regulatory / cytology
  • T-Lymphocytes, Regulatory / drug effects*
  • T-Lymphocytes, Regulatory / immunology
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism
  • Vasoactive Intestinal Peptide / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • B7-2 Antigen
  • Ccl22 protein, mouse
  • Cd86 protein, mouse
  • Chemokine CCL22
  • Immunologic Factors
  • Lipopolysaccharides
  • Micelles
  • Surface-Active Agents
  • Tumor Necrosis Factor-alpha
  • Vasoactive Intestinal Peptide