Abstract
Three cyclopentanoids (phlebiopsin A⁻C), one glycosylated p-terphenyl (methyl-terfestatin A), and o-orsellinaldehyde were isolated from the biocontrol fungus Phlebiopsis gigantea, and their structures were elucidated by 1D and 2D NMR spectroscopic analysis, as well as by LC-HRMS. The biological activity of the compounds against the root rot fungus Heterobasidion occidentale, as well as against Fusarium oxysporum and Penicillium canescens, was also investigated, but only o-orsellinaldehyde was found to have any antifungal activity in the concentration range tested.
Keywords:
Heterobasidion spp.; Phlebiopsis gigantea; biocontrol; cyclopentanoids; p-terphenyls; phanerochaetaceae; secondary metabolite characterization.
MeSH terms
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Agaricales / drug effects
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Aldehydes / chemistry
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Aldehydes / isolation & purification*
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Aldehydes / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Catechols / chemistry
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Catechols / isolation & purification*
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Catechols / pharmacology
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Chromatography, Liquid
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Cyclopentanes / chemistry
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Cyclopentanes / isolation & purification*
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Cyclopentanes / pharmacology
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Fusarium / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Penicillium / drug effects
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Plant Diseases / microbiology
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Plant Diseases / prevention & control*
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Plant Roots / drug effects
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Plant Roots / microbiology
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Polyporales / chemistry*
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Polyporales / growth & development
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Secondary Metabolism
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Terphenyl Compounds / chemistry
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Terphenyl Compounds / isolation & purification*
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Terphenyl Compounds / pharmacology
Substances
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Aldehydes
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Antifungal Agents
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Catechols
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Cyclopentanes
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Terphenyl Compounds
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o-orsellinaldehyde