Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma

Marc A Morgan; Ali Shilatifard

doi:10.1016/j.ccell.2018.05.011

Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma

Cancer Cell. 2018 Jun 11;33(6):951-953. doi: 10.1016/j.ccell.2018.05.011.

Authors

Marc A Morgan¹, Ali Shilatifard²

Affiliations

¹ Simpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA.
² Simpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA. Electronic address: ash@northwestern.edu.

PMID: 29894696
DOI: 10.1016/j.ccell.2018.05.011

Abstract

In this issue of Cancer Cell, McBride and colleagues report that the synovial sarcoma SS18-SSX fusion drives BAF complex recruitment to bivalent domains repressed by PRC2 complex to orchestrate aberrant transcriptional activation. Redistribution of BAF localization is a major driver of synovial sarcoma proliferation and presents a promising therapeutic target.

Publication types

Comment

MeSH terms

Adult
Cell Nucleus
Child
Epigenomics
Humans
Oncogene Proteins, Fusion / genetics
Sarcoma, Synovial*
Transcriptional Activation

Substances

Oncogene Proteins, Fusion