Four New Sesquiterpenoids from the Roots of Diarthron Tianschanica with Their Antineoplastic Activity

Molecules. 2018 Jun 8;23(6):1383. doi: 10.3390/molecules23061383.

Abstract

Four new sesquiterpenoids, known as diarthronchas A⁻D (14), and one known daphnauranol B (5) were isolated from the methanol extract of the roots of Diarthron tianschanica. The compounds structures were determined on the basis of spectroscopic data. All of the isolated compounds were profiled for their antineoplastic activity.

Keywords: Diarthron tianschanica; antineoplastic activity; sesquiterpenoids; thymelaeaceae.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Humans
  • Inhibitory Concentration 50
  • Plant Roots / chemistry*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology*
  • Spectrum Analysis / methods
  • Structure-Activity Relationship
  • Thymelaeaceae / chemistry*

Substances

  • Antineoplastic Agents
  • Sesquiterpenes