Biological effects of mixed-ion beams. Part 1: Effect of irradiation of the CHO-K1 cells with a mixed-ion beam containing the carbon and oxygen ions

Joanna Czub; Dariusz Banaś; Janusz Braziewicz; Iwona Buraczewska; Marian Jaskóła; Urszula Kaźmierczak; Andrzej Korman; Anna Lankoff; Halina Lisowska; Zygmunt Szefliński; Maria Wojewódzka; Andrzej Wójcik

doi:10.1016/j.apradiso.2018.05.028

Biological effects of mixed-ion beams. Part 1: Effect of irradiation of the CHO-K1 cells with a mixed-ion beam containing the carbon and oxygen ions

Appl Radiat Isot. 2018 Sep:139:304-309. doi: 10.1016/j.apradiso.2018.05.028. Epub 2018 May 30.

Authors

Affiliations

¹ Jan Kochanowski University, Institute of Physics, ul. Świętokrzyska 15, 25-406 Kielce, Poland. Electronic address: czub@ujk.edu.pl.
² Jan Kochanowski University, Institute of Physics, ul. Świętokrzyska 15, 25-406 Kielce, Poland; Holy Cross Cancer Center, ul. Arwińskiego 3, 25-734 Kielce, Poland.
³ Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warsaw, Poland.
⁴ National Centre for Nuclear Research, ul. Andrzeja Sołtana 7,Świerk, 05-400 Otwock, Poland.
⁵ Heavy Ion Laboratory at the University of Warsaw, ul. Pasteura 5a, 02-093 Warsaw, Poland.
⁶ Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland; Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warsaw, Poland.
⁷ Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland.
⁸ Department of Molecular Bioscience, Centre for Radiation Protection Research, The Wenner-Gren Institute, Stockholm University, Universitetsvagen 10, 114 18 Stockholm, Sweden; Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland.

PMID: 29883949
DOI: 10.1016/j.apradiso.2018.05.028

Abstract

Carbon and oxygen ions were accelerated simultaneously to estimate the effect of irradiation of living cells with the two different ions. This mixed ion beam was used to irradiate the CHO-K1 cells, and a survival test was performed. The type of the effect of the mixed ion beam on the cells was determined with the isobologram method, whereby survival curves for irradiations with individual ion beams were also used. An additive effect of irradiation with the two ions was found.

Keywords: Additive effect; CHO-K1 cells; Mixed ions beams.

MeSH terms

Animals
CHO Cells
Carbon / administration & dosage
Carbon / radiation effects
Carbon / therapeutic use*
Cell Survival / radiation effects
Cricetinae
Cricetulus
Dose-Response Relationship, Radiation
Heavy Ion Radiotherapy*
Linear Energy Transfer
Oxygen / administration & dosage
Oxygen / radiation effects
Oxygen / therapeutic use*
Radiometry
Relative Biological Effectiveness*

Substances

Carbon
Oxygen