New polyacetylenes glycoside from Eclipta prostrate with DGAT inhibitory activity

J Asian Nat Prod Res. 2019 Jun;21(6):501-506. doi: 10.1080/10286020.2018.1452914. Epub 2018 Jun 8.

Abstract

One new polyacetylene glycoside eprostrata Ⅰ (1), together with seven known compounds (2-8), were isolated from Eclipta prostrata. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated inhibitory activity on DGAT in an in vitro assay. Compounds 1-8 were found to exhibit inhibitory activity of DGAT1 with IC50 values ranging from 74.4 ± 1.3 to 101.1 ± 1.1 μM.

Keywords: Asteraceae; DGAT; polyacetylenic glucosides.

MeSH terms

  • Animals
  • Carbohydrate Conformation
  • Diacylglycerol O-Acyltransferase / antagonists & inhibitors*
  • Eclipta / chemistry*
  • Inhibitory Concentration 50
  • Liver / drug effects
  • Liver / enzymology
  • Magnetic Resonance Spectroscopy
  • Plant Stems / chemistry
  • Polyacetylene Polymer / chemistry*
  • Polyacetylene Polymer / pharmacology*
  • Rats

Substances

  • Polyacetylene Polymer
  • Dgat1 protein, rat
  • Diacylglycerol O-Acyltransferase