Abstract
Previous studies have shown that kynurenine may have convulsant activity. In the present investigation the intracerebroventricular injection of L- but not D-kynurenine induced convulsions in the rat. In vitro, L- but not D-kynurenine was able to displace 3H-GABA from rat brain membrane preparations. The action was specific for 3H-GABA and was not observed with other ligands. The data suggest that the convulsant activity of L-kynurenine might be due to an interaction with GABA receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bicuculline / pharmacology
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Binding, Competitive / drug effects
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Brain Chemistry / drug effects*
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In Vitro Techniques
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Injections, Intraventricular
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Kynurenine / administration & dosage
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Kynurenine / pharmacology*
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Male
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Membranes / metabolism
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Rats
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Rats, Inbred Strains
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Receptors, GABA-A / drug effects*
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Seizures / chemically induced
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Tryptophan / pharmacology
Substances
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Receptors, GABA-A
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Kynurenine
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Tryptophan
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Bicuculline