The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

Noni Novisari Soeroso; Rozaimah Zain-Hamid; Bintang Y M Sinaga; Ahmad Hamim Sadewa; Tamsil Syafiuddin; Elisna Syahruddin; Gino Tann; Erna Mutiara

doi:10.3889/oamjms.2018.224

The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

Open Access Maced J Med Sci. 2018 May 19;6(5):864-866. doi: 10.3889/oamjms.2018.224. eCollection 2018 May 20.

Authors

Noni Novisari Soeroso¹, Rozaimah Zain-Hamid², Bintang Y M Sinaga¹, Ahmad Hamim Sadewa³, Tamsil Syafiuddin¹, Elisna Syahruddin⁴, Gino Tann⁵, Erna Mutiara⁶

Affiliations

¹ Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155, Indonesia.
² Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155, Indonesia.
³ Department of Biochemistry, Faculty of Medicine, Gadjah Mada University, Jl. Farmako Sekip Utara, Yogyakarta 55281, Indonesia.
⁴ Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jl. Persahabatan Raya No.1, Jakarta 13230, Indonesia.
⁵ Department of Clinical Pathology, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155, Indonesia.
⁶ Department of Biostatistics, Faculty of Public Health, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155, Indonesia.

Abstract

Aim: This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers.

Method: This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia.

Results: Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index.

Conclusion: The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.

Keywords: Bataknese; Brinkman Index; Nicotine Dependence; Polymorphism of CYP2A6 gene.