The Lung and Esophagus: Developmental and Regenerative Overlap

Edward E Morrisey; Anil K Rustgi

doi:10.1016/j.tcb.2018.04.007

The Lung and Esophagus: Developmental and Regenerative Overlap

Trends Cell Biol. 2018 Sep;28(9):738-748. doi: 10.1016/j.tcb.2018.04.007. Epub 2018 Jun 2.

Authors

Edward E Morrisey¹, Anil K Rustgi²

Affiliations

¹ Division of Cardiovascular Medicine, Center for Pulmonary Biology, Cardiovascular Institute, Institute for Regenerative Medicine, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: emorrise@pennmedicine.upenn.edu.
² Division of Gastroenterology, Departments of Medicine and Genetics, Institute for Regenerative Medicine, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: anil2@pennmedicine.upenn.edu.

Abstract

Lung and esophageal development and organogenesis involve a complex interplay of signaling pathways and transcriptional factors. Once the lung and esophagus do separate, their epithelial proliferation and differentiation programs share certain common properties that may fuel adaptive responses to injury and subsequent regeneration. Lung and esophageal tissue organogenesis and regeneration provide perspectives on squamous cell cancers and adenocarcinomas in each tissue.

Keywords: Sox2; Trp63; development; esophagus; lung; regeneration.

Publication types

Review

MeSH terms

Carcinogenesis
Cell Differentiation
Esophagus / embryology*
Esophagus / physiology*
Gene Regulatory Networks
Humans
Lung / embryology*
Lung / physiology*
Regeneration / physiology*

Abstract

Publication types

MeSH terms

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