B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

Rodrigo Javier; Nawal Shaikh; Maciej S Lesniak; Adam Sonabend; Roger Stupp; Amir Behdad; Craig Horbinski

doi:10.1186/s13000-018-0717-9

B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

Diagn Pathol. 2018 Jun 5;13(1):37. doi: 10.1186/s13000-018-0717-9.

Authors

Rodrigo Javier¹, Nawal Shaikh², Maciej S Lesniak¹, Adam Sonabend¹, Roger Stupp¹, Amir Behdad³, Craig Horbinski^{4

5}

Affiliations

¹ Departments of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Tarry 2-705, 300 East Superior Street, Chicago, IL, 60611, USA.
² Departments of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
³ Departments of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
⁴ Departments of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Tarry 2-705, 300 East Superior Street, Chicago, IL, 60611, USA. craig.horbinski@northwestern.edu.
⁵ Departments of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. craig.horbinski@northwestern.edu.

Abstract

Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have been described in which the first detected intracerebral lesions are non-neoplastic, and are composed mostly of perivascular T cells, not B cells. This phenomenon is known as "sentinel lesions."

Keywords: Diffuse large B cell lymphoma; Primary CNS lymphoma; Sentinel lesion.

Publication types

Case Reports

MeSH terms

B-Lymphocytes / pathology*
Brain Neoplasms / pathology*
Humans
Lymphoma, Large B-Cell, Diffuse / pathology*
Male
Middle Aged
Precancerous Conditions / pathology*