Abstract
One cyclopalladated ferrocene compound CP was synthesized, which showed a good cell cytotoxicity. Assisted by a dual-targeting drug delivery system, the anticancer activity of CP to MDA-MB-468 remained unchanged, but the toxicity to non-tumorigenic cell line NIH3T3 was remarkably reduced. This provided a new path for the development of cyclopalladated ferrocene as an antitumor drug candidate.
MeSH terms
-
Animals
-
Antineoplastic Agents / administration & dosage*
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Cell Proliferation / drug effects
-
Drug Delivery Systems*
-
Ferrous Compounds / administration & dosage*
-
Ferrous Compounds / chemical synthesis
-
Ferrous Compounds / chemistry
-
Ferrous Compounds / pharmacology*
-
Humans
-
Hyaluronic Acid / chemistry*
-
Metallocenes / administration & dosage*
-
Metallocenes / chemical synthesis
-
Metallocenes / chemistry
-
Metallocenes / pharmacology*
-
Mice
-
Micelles
-
NIH 3T3 Cells
-
Organometallic Compounds / chemical synthesis
-
Organometallic Compounds / chemistry
-
Organometallic Compounds / pharmacology*
-
Particle Size
-
Surface Properties
-
beta-Cyclodextrins / chemistry*
Substances
-
Antineoplastic Agents
-
Ferrous Compounds
-
Metallocenes
-
Micelles
-
Organometallic Compounds
-
beta-Cyclodextrins
-
Hyaluronic Acid
-
betadex
-
ferrocene