Astatine-211 imaging by a Compton camera for targeted radiotherapy

Yuto Nagao; Mitsutaka Yamaguchi; Shigeki Watanabe; Noriko S Ishioka; Naoki Kawachi; Hiroshi Watabe

doi:10.1016/j.apradiso.2018.05.022

Astatine-211 imaging by a Compton camera for targeted radiotherapy

Appl Radiat Isot. 2018 Sep:139:238-243. doi: 10.1016/j.apradiso.2018.05.022. Epub 2018 May 24.

Authors

Yuto Nagao¹, Mitsutaka Yamaguchi², Shigeki Watanabe³, Noriko S Ishioka⁴, Naoki Kawachi⁵, Hiroshi Watabe⁶

Affiliations

¹ Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292, Japan; Graduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan. Electronic address: nagao.yuto@qst.go.jp.
² Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292, Japan. Electronic address: yamaguchi.mitsutaka@qst.go.jp.
³ Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292, Japan. Electronic address: watanabe.shigeki@qst.go.jp.
⁴ Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292, Japan. Electronic address: ishioka.noriko@qst.go.jp.
⁵ Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292, Japan. Electronic address: kawachi.naoki@qst.go.jp.
⁶ Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292, Japan; Graduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan; Cyclotron and Radioisotope Center, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. Electronic address: watabe@cyric.tohoku.ac.jp.

PMID: 29864741
DOI: 10.1016/j.apradiso.2018.05.022

Abstract

Astatine-211 is a promising radionuclide for targeted radiotherapy. It is required to image the distribution of targeted radiotherapeutic agents in a patient's body for optimization of treatment strategies. We proposed to image ²¹¹At with high-energy photons to overcome some problems in conventional planar or single-photon emission computed tomography imaging. We performed an imaging experiment of a point-like ²¹¹At source using a Compton camera, and demonstrated the capability of imaging ²¹¹At with the high-energy photons for the first time.

Keywords: Astatine-211; Compton camera; Monte Carlo simulation; Targeted radiotherapy.

MeSH terms

Alpha Particles / therapeutic use
Astatine / therapeutic use*
Computer Simulation
Humans
Monte Carlo Method
Neoplasms / diagnostic imaging
Neoplasms / radiotherapy
Photons
Radionuclide Imaging / instrumentation*
Radionuclide Imaging / statistics & numerical data
Radiopharmaceuticals / therapeutic use
Radiotherapy / instrumentation*
Radiotherapy / statistics & numerical data

Substances

Astatine-211
Radiopharmaceuticals
Astatine